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KMID : 0370220220660050217
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Yakhak Hoeji
2022 Volume.66 No. 5 p.217 ~ p.224
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Inhibitory Effect of Nimbolide on Mast Cell Degranulation and Allergic Asthma in Mice
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Lee Jung-Eun
Im Dong-Soon
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Abstract
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The Indian neem tree has been used for treating several medical conditions. Nimbolide, an active compoundpresent in the leaves of the Indian neem tree, has shown anti-inflammatory effects in several animal models. However, itsefficacy against allergic asthma has not been examined. Therefore, we investigated the effects of nimbolide on mast celldegranulation and ovalbumin-induced allergic asthma in mice. Nimbolide administration inhibited antigen-induced degranulationof RBL-2H3 cells in a concentration-dependent manner and reduced the immune cell numbers by suppressing theexpression of inflammatory cytokines, such as IL-4, IL-13, IFN-γ, IL-33, and thymic stromal lymphopoietin (TSLP) in thebronchoalveolar lavage fluid. Histological studies also demonstrated the in vivo efficacy of nimbolide, evident from thereduced number of periodic acid-Schiff-stained cells and inflammatory scores in the lungs. Furthermore, nimbolideadministration inhibited the increase of IL-13 levels, but not that of serum IgE levels. These results demonstrate thetherapeutic potential of nimbolide against allergic asthma.
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KEYWORD
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Asthma, Allergy, Neem, Nimbolide
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